Nanotechnology is a dynamic branch of science that transforms and manipulates substances on a molecular and even atomic level. Liposomes refer to microscopic cellular bubbles made of materials called phospholipids, which are similar to human cell material and are both attracted to and repelled by water. Liposomal formulation helps create these structures for use in the targeted delivery of medication.
The significance of these vesicular containers containing soluble molecules first became apparent soon after they appeared during the 1960s. Pharmacists as well as researchers recognized their potential for safely and slowly administering specific pharmaceuticals important to treating cancer and other illnesses. The new method could target undesirable cells more efficiently, and had fewer side issues associated with some medications.
The concept they use is radically different because it does not depend of standard modes of absorption typical of IV or oral administration. Conventional chemical processes can make management of specialized drugs more difficult. They are indiscriminate in their toxicity, and affect healthy organs as well, resulting in unnecessary damage and more lengthy recovery. When delivered via liposomes, release of toxic medication can be better controlled.
The drug molecules encased within each structure are suspended in water and surrounded by an artificially or naturally created membrane. The formulation of designed liposomes turns them into ideal mechanisms for hydrophilic drugs, or those that are attracted to and become suspended in water. When prepared according to current methods, the structures exist in two primary types, unilammelar or multilammelar. There are subcategories that include different sizes.
Individual liposomes surround the drug molecules with a membrane, and then transfer those medications to other cells when activated. Molecules can be released into the body by fusing certain layers with other physical cells, effectively delivering a small amount of medication. Others strategies rely on chemical reactions that encourage diffusion on a molecular level. The net result is a steadier, more controlled release.
Not only can this process be more easily managed by physicians, but it leaves no residual toxins behind, and is compatible biologically with human cells. Comparatively recent developments in ultrasound technology use sound waves to activate these chemical invaders, increasing their strength in regions where it is most needed. Others are being administered via the respiratory system, where they are deposited in the lungs and slowly released.
Manufacturing these tiny capsules for medical purposes is still expensive. As research continues and use becomes more widespread, costs will likely decrease, but will still remain substantial. Because the technology is still relatively new, many issues have yet been completely resolved. Some types of artificial cells have experienced problems with wall leakage, while others are still affected by natural degradation processes such as oxidation.
Like some other medical innovations, liposomes are now being introduced into consumer products. They are currently promoted as a beneficial way to administer herbal, vitamin and mineral supplements, and some individuals have created their own unique formulations. Although commercial applications produce controversy regarding efficacy, the continued development of new processes provides the basis for more effective medical uses.
The significance of these vesicular containers containing soluble molecules first became apparent soon after they appeared during the 1960s. Pharmacists as well as researchers recognized their potential for safely and slowly administering specific pharmaceuticals important to treating cancer and other illnesses. The new method could target undesirable cells more efficiently, and had fewer side issues associated with some medications.
The concept they use is radically different because it does not depend of standard modes of absorption typical of IV or oral administration. Conventional chemical processes can make management of specialized drugs more difficult. They are indiscriminate in their toxicity, and affect healthy organs as well, resulting in unnecessary damage and more lengthy recovery. When delivered via liposomes, release of toxic medication can be better controlled.
The drug molecules encased within each structure are suspended in water and surrounded by an artificially or naturally created membrane. The formulation of designed liposomes turns them into ideal mechanisms for hydrophilic drugs, or those that are attracted to and become suspended in water. When prepared according to current methods, the structures exist in two primary types, unilammelar or multilammelar. There are subcategories that include different sizes.
Individual liposomes surround the drug molecules with a membrane, and then transfer those medications to other cells when activated. Molecules can be released into the body by fusing certain layers with other physical cells, effectively delivering a small amount of medication. Others strategies rely on chemical reactions that encourage diffusion on a molecular level. The net result is a steadier, more controlled release.
Not only can this process be more easily managed by physicians, but it leaves no residual toxins behind, and is compatible biologically with human cells. Comparatively recent developments in ultrasound technology use sound waves to activate these chemical invaders, increasing their strength in regions where it is most needed. Others are being administered via the respiratory system, where they are deposited in the lungs and slowly released.
Manufacturing these tiny capsules for medical purposes is still expensive. As research continues and use becomes more widespread, costs will likely decrease, but will still remain substantial. Because the technology is still relatively new, many issues have yet been completely resolved. Some types of artificial cells have experienced problems with wall leakage, while others are still affected by natural degradation processes such as oxidation.
Like some other medical innovations, liposomes are now being introduced into consumer products. They are currently promoted as a beneficial way to administer herbal, vitamin and mineral supplements, and some individuals have created their own unique formulations. Although commercial applications produce controversy regarding efficacy, the continued development of new processes provides the basis for more effective medical uses.
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